PENGARUH METODE KONTRASEPSI SUNTIK 3 BULAN (DMPA) TERHADAP FUNGSI SEKSUAL DAN BERAT BADAN Scooping Review

Gaidha Khusnul Pangestu; Eugenius Phyowai Ganap; Anjarwati Anjarwati

Authors

Gaidha Khusnul Pangestu Universitas Aisyah Yogyakarta
Eugenius Phyowai Ganap Universitas Aisyah Yogyakarta
Anjarwati Universitas Aisyah Yogyakarta

Keywords:

DMPA, Progestine Only, Sexual Function, Weight Gain

Abstract

Efek samping dari penggunaan kontrasepsi progestine only adalah menurunnya fungsi seksual dan adanya penambahan berat badan. Hal tersebut banyak menjadi masalah bagi akseptor, karena akan mempengaruhi kualitas hidup. Tujuan dari scoping review ini adalah untuk melakukan tinjauan atau ulasan dan menyimpulkan literatur yang meneliti tentang pengaruh kontrasepsi progestine-only terhadap fungsi seksual dan berat badan.Metode menggunakan scooping review, pencarian artikel dilakukan dengan menggunakan dua database, yaitu pubmed dan science direct. Kata kunci utama yang digunakan untuk pencarian artikel adalah “Depomedroxy progesterone acetat”, “progestine only”, “sexual function”, “weight gain”. Hasil dari tinjauan ini memunculkan 8 tema kontrasepsi progestine only mempengaruhi fungsi seksual dan 7 tema kontrasepsi progestine only mempengaruhi berat badan. Terdapat efek samping dari kontrasepsi hormonal progestine only terhadap fungsi seksual. Walaupun memberikan pengaruh yang signifikan, tetapi jika dibandingkan dengan kontrasepsi selain progestine only tidak terlalu jauh perbedaannya. Berbeda pada efek samping kenaikan berat badan, terjadi perubahan yang cukup signifikan karena adanya peningkatan retensi cairan tubuh, kenaikan nafsu makan yang terjadi karena adanya perubahan hormon dalam tubuh wanita

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References

Agota Malmborg, Elin Persson, Jan Brynhildsen & Mats Hammar. Hormonal contraception and sexual desire: A questionnaire-based study of young Swedish women. Hormonal contraception and sexual desire: A questionnaire-based study of young Swedish women. 2016. The European Journal of Contraception & Reproductive Health Care, 21:2, 158-167, DOI: 10.3109/13625187.2015.1079609

Ahmed Mohamed Hassanin, Ahmed Mohamed El-Halwagy, Nashaat N Ismail & Basma Atef Shehab. A study of the impact of the commonly used female contraceptive methods in Egypt on female sexual function, Journal of Sex & Marital Therapy, 2018 DOI: 10.1080/0092623X.2018.1437579

Al-Youzbaki WB. C-reactive protein and lipid profile among depomedroxyprogesterone acetate Injections users. J Ann Coll Med Mosul. 2011;37(2):48–56.

Amanda Boozalis, BA, Nhial T. Tutlam, MPH, Camaryn Chrisman Robbins, MD, MPH, Jeffrey F. Peipert, MD, PhD. Sexual Desire and Hormonal Contraception. 2016. The American College of Obstetricians and Gynecologists, ISSN: 0029-7844/16

Andrea E. Bonny, MD, Michelle Secic, MS, and Barbara Cromer, MD. Early Weight Gain Related to Later Weight Gain in Adolescents on Depot Medroxyprogesterone Acetat. 2011. Obstet Gynecol 2011;117:793–7). DOI: 10.1097/AOG.0b013e31820f387c

Andrea E. Bonny, MD, Michelle Secic, MS, and Barbara Cromer, Early Weight Gain Related to Later Weight Gain in Adolescents on Depot Medroxyprogesterone Acetate. 2011. MD VOL. 117, NO. 4, OBSTETRICS & GYNECOLOGY 793

a. Schafﬁr, MD; Michelle M. Isley, MD, MPH; Megan Woodward, Oral contraceptives vs injectable progestin in their effect on sexual behavior, Jonathan, Ohio State University College of Medicine, Ohio, 20120, doi: 10.1016/j.ajog.2010.07.024

Bakry S, Merhi ZO, Skala TJ, Mahmoud MS, Fadiel A, Naftolin F. Depot-medroxyprogesterone acetate: update. Arch Gynecol Obstet 2008; 278: 1 - 2.

Bakry S, Merhi ZO, Scalise TJ, Mahmoud MS, Fadiel A, Naftolin F. Depot-medroxyprogesterone acetate: an update. Arch Gynecol Obstet 2008;278:1–2.

Batlajery, J., Hamidah., & Mardiana. (2014). The use of the Dmpa injection contraceptive method associated with female sexual dysfunction in injection Kb acceptors. Poltekkes Kemenkes Jakarta III: Jakarta.

Berenson AB , Rahman M . Changes in weight, total fat, percent body fat, and central-to-peripheral fat ratio associated with injectable and oral contraceptive use. Am J Obstet Gynecol 2009 ; 200:329 . e1 – 8.

Bonny AE, Lange HL, Rogers et al . A pilot study of depot medroxyprogesterone acetate pharmacokinetics and weight gain in adolescent female . Contraception 2014 ; 89 : 357 – 60 .

Buppasiri P. Progestin-only contraceptives: effects on weight. The WHO Reproductive Health Library. Geneva: World Health Organization; 2012.

Clark MK, Dillon JS, Sowers M, Nichols S. Weight, fat mass, and central distribution of fat increase when women use depot-medroxyprogesterone acetate for contraception. Int J Obes 2005;29:1252–8.

Fagan PF, Churchil A. The effects of divorce in children. Marriage & Religion Research Institute: Washington; 2012.

Filipa de Castro Coelho, Cremilda Barros. The Potential of Hormonal Contraception to Influence Female Sexuality. Portugal. 2019. https://doi.org/10.1155/2019/9701384

Firoozeh Veisi; M.D. , Maryam Zangeneh; M.D. Comparison of Two Different Injectable Contraceptive Methods: Depo-medroxy Progesterone Acetate (DMPA) and Cyclofem. 2012. Iran

Flegal KM, Carroll MD, Kit BK, Ogden CL. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999–2010. JAMA 2012;307:491–7.

Gai L, Zhang J, Zhang H, Gai P, Zhou L, Liu Y. The effect of depot medroxy progesterone acetate (DMPA) on bone mineral density (BMD) and evaluating changes in BMD after discontinuation of DMPA in Chinese women of reproductive age. Contraception 2011; 83:218-22.

Gallo MF, Lopez LM, Grimes DA, Schulz KF, Helmerhorst FM. Combined contraception: effect on body weight. Cochrane Database Syst Rev 2011; 9 CD003987.

Giti Ozgoli, Zohre Sheikhan, Mahrokh Dolatian, Masoumeh Simbar, Maryam Bakhtyari, Malihe Nasiri, Comparison of Sexual Dysfunction in Women Using Depo-Medroxyprogesterone Acetate (DMPA) and Cyclofem, J Reprod Infertil, Vol 16, No 2, 2015

Guazzelli CA, Jacobucci MS, Barbieri M, Araujo FF, Moron AF. Monthly injectable contraceptive use by adolescents in Brazil: evaluation of clinical aspects. Contraception 2007; 76:45-8.

Guilbert ER, Brown JP, Kaunitz AM, et al. The use of depotmedroxyprogesterone acetate in contraception and its potential impact on skeletal health. Contraception 2009;79:167–77.

Hassan RS, Eraky EM, Khatwa aMa, Ghonemy GI. Studi the effect of hormonal contraceptive method on female sexual function. Med J Cairo Univ. 2014;83(1):115-20.

Hassan DF, Petta CA, Aldrighi JM, Bahamondes L, Perrotti M. Weight variation in a cohort of women using copper IUD for contraception. Contraception 2003;68:27–30.

Ismail I, Keating SE, Baker MK, Johnson NA. A systematic review and meta-analysis of the effect of aerobic vs. resistance exercise training on visceral fat. Obes Rev 2012;13:68–91.

Jaleen Sims, Elizabeth Lutz, Kedra Wallace, Wondwosen Kassahun-Yimer, Chiamaka Ngwudike & James Shwayder. Depo-medroxyprogesterone acetate, weight gain and amenorrhea among obese adolescent and adult women. 2020. The European Journal of Contraception & Reproductive Health Care, DOI: 10.1080/13625187.2019.1709963

Jenny A. Higgins, Nicole K. Smith. The Sexual Acceptability of Contraception: Reviewing the Literature and Building a New Concept. Wisconsin. 2016. DOI: 10.1080/00224499.2015.1134425

Karastergiou K, Smith SR, Greenberg AS, Fried SK. Sex differences in human adipose tissues – the biology of pear shape. Biol Sex Differ 2012;3:13.

Kemenkes RI. (2013). Situasi Keluarga Berencana Diindonesia. Jakarta: Buletin Jendela Data dan Informasi Kesehatan.

Lange HL, Belury MA, Secic M, Thomas A, Bonny AE. Dietary intake weight gain among adolescents on depot medroxyprogesterone acetate. J Pediatr Adolesc Gynecol. 2015;28:139–43.

Laureen M Lopez, Alison Edelman, Mario Chen, Conrad Otterness. Progestin-only contraceptives: effects on weight. USA. 2013.

Le YC, Rahman M, Berenson AB. Early weight gain predicting later weight gain among depot medroxyprogesterone acetate users. Obstet Gynecol 2009;114:279 – 84.

Lopez LM, Edelman A, Chen M, Otterness C, Trussell J, Helmerhors FM Progestin-only contraceptives: effects on body weight. Cochrane Database of Systematic Review 2013, 7th edition. Ogden CL, Carroll MD, Kit BK, Flegal KM.

Lopez LM, Edelman A, Chen-Mok M, Trussell J, Helmerhorst FM. Progestin-only contraceptives: effects on weight. Cochrane Database Syst Rev 2011;4 CD008815.

Magdalena Zgliczynska, Martyna Rowniak, Iwona Szymusik, Aleksandra Sierocinska, Armand Bajaka, Katarzyna Kosinska-Kaczynska, Nicole Sochacki-Wojcicka, Miroslaw Wielgos, Contraceptive Behaviors in Polish Women Aged 18–35—A Cross-Sectional, Study Poland Department of Obstetrics and Gynecology, 2018;

Maria Val é ria Bahamondes, Priscilla de Nazar é Silva dos Santos, Waleska Oliveira Modesto, Nathalia Dal ’ Ava, Elizabeth Jo ã o Pavin, Arlete Fernandes. Body composition and weight gain in new users of the three-monthly injectable contraceptive, depot-medroxyprogesterone acetate, after 12 months of follow-up. 2014. Brazil. The European Journal of Contraception and Reproductive Health Care, 2014; 19: 432–438

Moher D, Larissa Shamseer, Mike Clarke, Davina Ghersi, Alessandro Liberati, Mark Petticrew, Paul Shekelle, Lesley A Stewart, PRISMA-P Group. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. 2015. DOI: 10.1186/2046-4053-4-1

Muluken Fekadie Zerihun, Tabarak Malik, Yohannes Mulu Ferede, Tesfahun Bekele, Yigizie Yeshaw Zerihun et al. Changes in body weight and blood pressure among women using Depo-Provera injection in Northwest Ethiopia. 2019. https://doi.org/10.1186/s13104-019-4555-y

Natália Dal'Ava, Luis Bahamondes, M. Valeria Bahamondes, Bruna F. Bottura, Ilza Monteiro. Body weight and body composition of depot medroxyprogesterone acetate users. 2014. the National Institute of Hormones and Women's Health, 13084–971, Campinas, SP, Brazil

Nerea M. Casado-Espada, Rubén de Alarcón,Javier I. de la Iglesia-Larrad, Berta Bote-Bonaechea, Ángel L. Montejo, Hormonal Contraceptives, Female Sexual Dysfunction, and Managing Strategies: A Review, 2019, J Clin Med, doi: 10.3390/jcm8060908

Paul Enzlin, MA, PhD, Steven Weyers, MD, PhD, Dirk Janssens, MD, Jean-Jacques Amy, MD, DTM Willy Poppe, MD, Christa Eelen, MD, Els Pazmany MA, Sexual Functioning in Women Using Levonorgestrel-Releasing Intrauterine Systems as Compared to Copper Intrauterine Devices, 2012, J Sex Med 2012;9:1065–1073

Sikolia Z. Wanyonyi, William R. Stones, Evan Sequeira, Health-related quality of life changes among users of depot medroxyprogesterone acetate for contraception, Department of Obstetrics and Gynaecology, Kenya, 2011

Trussell J. Contraceptive failure in the United States. Contraception 2011;83:397–404.

Vickery Z , Madden T , Zhao Q , et al . Weight change at 12 months in users of three progestin-only contraceptive methods. Contraception. 2013

Westhoff C, Jain JK, Milson I, Ray A. Changes in weight with depot medroxyprogesterone acetate subcutaneous injection 104 mg/0,65 ml. Contraception 2007;75:261–7.

Westhoff C , Jain JK , Milsom I , et al . Changes in weight with depot medroxyprogesterone acetate subcutaneous injection 104 mg/0.65 mL . Contraception 2007 ; 75 : 261 – 7 .

Zevidah Vicker, Jenifer E. Allsworth, Tessa Madden, Qiuhong Zhao, Gina M. Secura, Jeffrey F. Peipert. Weight change at 12 months in users of three progestin-only contraceptive methods. 2012. Division of Clinical Research, Washington University School of Medicine, Saint Louis, MO, USA